PDRN vs PN: The Next Big Thing in K-Beauty?

What is PDRN and Why is It So Popular?

Move over retinol, centella, and hyaluronic acid—there’s a new star ingredient taking over the K-beauty scene! PDRN (Polydeoxyribonucleotide) is an ingredient derived from salmon or trout DNA, known for its skin regeneration and repair properties. Because of its structural similarity to human DNA, PDRN is highly stable and helps trigger cytokine production, leading to accelerated cell healing and anti-inflammatory effects.

While this isn’t a completely new ingredient, many skincare brands are now using PDRN as a key selling point in their products. Some even include it in the product name itself, signaling a growing trend that’s expected to dominate the beauty industry.

The Connection Between PDRN and PN: What’s the Difference?

If you’ve ever heard of Rejuran, the popular Korean skin booster injection, you’re already familiar with PN (Polynucleotide). First introduced in 2014, Rejuran injections quickly became a must-have treatment in dermatology clinics due to their effectiveness in improving skin elasticity, texture, and hydration. As a result, skincare brands leveraged this trend by introducing PDRN-infused cosmetics for at-home use.

However, PN and PDRN are not the same—even though they come from the same source.

• PN (Polynucleotide): Used in professional treatments like Rejuran injections. It has a larger molecular structure, requiring direct injection into the dermis for optimal results. It’s ideal for deep wrinkle and scar improvement.

• PDRN (Polydeoxyribonucleotide): Used in skincare products. It works on the epidermis, helping to repair the skin barrier and reduce inflammation. Since it has a smaller molecular size, it can be applied topically and still deliver visible benefits.

PN Injections vs. PDRN Skincare: Which One is Right for You?

"Rejuran skin boosters are known to be quite painful," says Dr. Moon Deuk Gon from Mipa Moon Dermatology. The needle injections can cause swelling and discomfort, and some people don’t see dramatic changes despite undergoing the procedure. For these individuals, using PDRN-infused skincare might be a better alternative.

Dr. Lee So Hyun from Nucleic Clinic also points out that not everyone is a good candidate for injection treatments. "If your skin barrier is weak, or if you have conditions like atopic dermatitis or sensitivity to metals and preservatives, injections could be too harsh. In such cases, medical-grade PDRN creams can be a safer and more effective option."

How to Maximize PDRN’s Benefits in Skincare

If you’ve already had a PN injection, incorporating PDRN skincare can help extend the effects of your treatment. The best way to use PDRN products is to layer a lightweight serum multiple times, allowing your skin to gradually absorb the active ingredients.

Pro Tip:
According to Kim Ki Min, marketing director of Anua (a popular K-beauty brand known for its PDRN skincare line), "Applying a PDRN serum in thin layers ensures better absorption and longer-lasting results. You can also use a skincare device after application for enhanced penetration."

Not All PDRN Serums Are the Same!

The effectiveness of PDRN skincare depends on several factors:
✔ Manufacturing process – Rejuran Cosmetics holds a patented DOTⓇ (DNA Optimizing Technology) that enhances PDRN purity and absorption.
✔ Delivery system – Anua’s PDRN line uses Smart Capsule Technology, where oil-coated capsules improve penetration and efficacy.
✔ Concentration – Higher concentrations of PDRN result in a thicker texture, creating an occlusive, moisture-locking effect on the skin.

Since PDRN serums vary in formulation, it’s best to choose one based on your skin type, seasonal needs, and desired skincare benefits.

Final Thoughts

With its anti-aging, skin-repairing, and inflammation-reducing properties, PDRN is making its way from dermatology clinics to everyday skincare routines. Whether you opt for an in-clinic PN injection or a PDRN serum for daily maintenance, this powerhouse ingredient is here to stay in K-beauty.

 

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